· Gas Sensing Solutions (GSS) was founded over ten years ago on the concept of using midinfrared LEDs at the heart of our sensors. This differs to the source of infrared typically used by other providers which use significantly more power and requires devices to be plugged into a mains supply. Across our 3 families of products, we produce a standard range of sensors to suit many …
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· The cGASSTING Pathway for DNA Sensing. cGAS binds dsDNA using a “zinc thumb” structure and a positively charged surface. DNA association induces a structural switch that repositions the catalytic residues to bind the GTP and ATP substrates mediated by magnesium ions. The catalysis proceeds from a 2′5′ GpA linkage to a 3′5 ApG ...
Gas Sensing Solutions Axetris AG is a designer and OEM manufacturer of Laser Gas Detection (LGD) solutions based on Tunable Diode Laser Spectroscopy (TDLS). The TDLS technology provides a valid solution to many gas detection challenges. We support our OEM customers with indepth technology and application expertise from feasibilities until product launch. We collaborate with you in finding ...
· Cells detect microbial and selfDNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNAsensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al. uncovered two mechanisms that prevent cGAS from being activated by the chromatin DNA (see the Perspective by Ablasser).
· Abstract. Detection of viral DNA by cyclic GMP‐AMP synthase (cGAS) is a first line of defence leading to the production of type I interferon (IFN). As HIV‐1 replication is not a strong inducer of IFN, we hypothesised that an intact capsid physically cloaks viral DNA from cGAS.
· cGAS (also known as C6orf150, or male abnormal 21 domain containing 1 (MAB21D1)) is located on chromosome 6q13 and encodes a protein with 522 amino acids in human. Mechanistically, cGAS recognizes ...
· Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a …
· Why the HIV2 viral capsid, unlike the capsid of HIV1, fails to protect RT products from innate sensors is the subject of ongoing investigation, but given that HIV2 does not replicate in dendritic cells and macrophages (Duvall et al, 2007; Chauveau et al, 2015) these observations suggest that evasion of sensing by cGAS is a necessary ...
· Civril, F. et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498 , 332–337 (2013). ADS CAS PubMed PubMed Central Article Google Scholar
· Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclicdinucleotide, 2′3′cGAMP, as the secondary messenger to bind and activate STING for subsequent production of type I interferons and other immunemodulatory genes. Hyperactivation of cGAS …
· acidsensing cGAS and AIM2 inflammasome by binding to these molecules in a manner that is competitive with immunestimulatory DNA (Kaminski et al, 2013; Steinhagen et al, 2018). However, whether pharmacologically antagonizing dsDNAsensing cGAS via A151 could govern pyroptosis and the overall neuroinflammation in the context of brain ischemia still remains poorly defined. Results …
Cyclic GMPAMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger 2''3''cGAMP and controls activation of innate immunity in mammalian cells 15. Animal genomes typically encode multiple proteins with predicted homology to cGAS 610, but the function of these uncharacterized enzymes is unknown. Here we show that cGASlike receptors (cGLRs) are innate …
· To further investigate dsDNAsensing cGAS activation and pyroptosis in microglia with a more dsDNArelevant stimulus, ... Tamoxifen was given as a solution in corn oil by intraperitoneally () for five doses of 75 mg, separated by 5 days. Four weeks after the last dose of tamoxifen, the mice were subjected to surgery. The animals were randomized into different experimental groups. To avoid ...
· September 2016 – Mit der schottischen Gas Sensing Solutions Ltd. (GSS) und der Schweizer Pewatron AG gehen zwei wichtige Vertreter der SensortechnologieBranche eine Partnerschaft ein. Über Pewatron sind die äusserst zuverlässigen, innovativen Gassensoren von Gas Sensing Solutions (GSS) künftig auch in Deutschland, der Schweiz und Österreich erhältlich. Die …
SST Sensing Ltd’s primary goal is to provide sensing solutions to customers. We are suppliers of oxygen sensors and gas sensors.
· KSHV ORF52 prevents cGAS DNA sensing by directly inhibiting cGAS enzymatic activity • The inhibition of cGAS by ORF52 requires binding to both DNA and cGAS • The inhibition of cGAS by ORF52 is conserved among gammaherpesviruses • KSHV can elicit cGASdependent immune responses that are counteracted by ORF52
ular explanation of hcGAS DNA sensing specificity. These efforts in turn have not only allowed the design of a site ... FullLength cGAS Proteins Can Exist as DNAFree Dimers in Solution. cGAS is composed of a flexible Nterminal domain and a Cterminal catalytic domain (designated cGASCD)(, Upper). We found that DNAfree fulllength (FL) hcGAS and mcGAS exist as dimers in solution ...
· Inhibition of cGAS DNASensing Signaling by KSHV ORF52 (A) KSHV ORF52 inhibits cGASinduced IFNβ promoter activity. HEK293TSTING cells were transfected with IFNβ luciferase reporter and expression plasmids as indicated, and luciferase activity was assayed 24 hr after transfection. The relative luciferase activity was expressed as arbitrary units by normalizing firefly …
· The aberrant activation by DNA sensing pathway can result in inflammatory and autoimmune diseases, such as systemic lupus erythematosus. However, how host limits excessive or detrimental immune responses to viral DNA and mtDNA is not well elucidated. Thus, it is pressing to define the protective mechanisms that prevent aberrant activation of cGASmediated innate immunity. …
· Edinburgh Sensors: gas sensing solutions manufactured in the UK. If you are struggling to find the right gas sensor for your business, why not contact us and we will be happy to talk you through our range of gas detection instruments to help you find the most suitable gas detector system to …
· IFNA, IFNB and CXCL10 transcript levels were decreased in TRAMPC2 and DU145 cells transfected with cGAS siRNAs and cGASdeficient A549, HeLa, and HCT116 cells (Fig. 3C) demonstrating that sensing ...
Der CozIR®Blink CO2Sensor von Gas Sensing Solutions ist unser bisher stromsparendster CO2Sensor und der NDIRCO2Sensor mit dem geringsten Stromverbrauch auf dem Markt! Entwickelt und hergestellt in Großbritannien, ermöglicht dieser Kohlendioxidsensor mit extrem niedrigem Stromverbrauch dem Benutzer, den Stromverbrauch je nach Bedarf und Anwendung zu steuern. Der …
GrayWolf Sensing Solutions Since 1998, the worldwide market leader in high performing portable, datalogging and longterm fixed monitoring indoor air quality (IAQ) meters and monitors. Advanced sensor, instrumentation, software and reporting technology for superior environmental test instrumentation in facilities from schools to hospitals to office/government buildings to manufacturing …
We investigated the roles of protein 204 (p204) and cyclic guanosineadenosine synthetase (cGAS) sensors during infection with mou … Immune sensing of mouse polyomavirus DNA by p204 and cGAS DNA sensors FEBS J. 2021 May 10. doi: / Online ahead of print. Authors Boris Ryabchenko 1 , Irina Soldatova 1 , Vojtech Šroller 1 , Jitka Forstová 1 , Sandra Huérfano 1 Affiliation 1 ...
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